Semaglutide, an antidiabetic drug used to treat type 2 diabetes, is also an antiobesity drug used for long-term weight management. It was developed by Novo Nordisk in 2012. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1) and can be injected subcutaneously or taken orally. Semaglutide is a glucagon-like peptide 1 receptor agonist.The current common specifications are: 2mg/5mg/10mg, with prices ranging from 75, 120, and 230. There are some changes depending on the specifications and quantity.Semaglutide appears as a white powder and semi-solid. Currently, the appearance and packaging can be customized on demand, and labels can be mailed with the package.
|
Abbreviation |
Sermaglutide |
|
Nickname |
Sermaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;semaglutide;Sermaglutide CAS 910463 68 2;Ozempic |
|
Associated title |
Ozempic |
|
CAS number |
910463-68-2 |
|
Molecular formula |
C187H291N45O59 |
What kind of medicine is this?
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs. It mimics the GLP-1 hormone, released in the gut in response to eating.
One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose). For that reason, health care providers have used semaglutide for more than 15 years
to treat Type 2 diabetes.
But GLP-1 in higher amounts also interacts with the parts of the brain that suppress your appetite and signal you to feel full. When used in conjunction with diet and exercise, it can cause
significant weight loss — and a reduced risk of cancer, diabetes and heart disease — in people who are obese or overweight.
How should I use this medication?
This medicine is given as an injection under the skin in the thigh (thigh), stomach, or upper arm. Give once a week (every 7 days). You will learn how to prepare and take this medication. Use
exactly as directed. Take your medicine regularly. Do not take more often than directed.
If you are using this medication with insulin, you should give this medication and insulin injections separately. Don't mix them together. Do not give injections closely together. Change (rotate)
the injection site with each injection.
It is important to place used needles and syringes in a special sharps container. Don't put them in the trash. If you don't have a sharps container, call your pharmacist or care team to get one.
The pharmacist will provide you with a special MedGuide with each prescription and refill. Please be sure to read this information carefully each time.
This medication comes with instructions for use. Ask your pharmacist for instructions on how to use this medication. Read the information carefully. If you have questions, talk to your pharmacist
or care team.
Discuss the use of this medication in children with your care team. May require special attention.
Overdose: If you think you have taken too much medicine, contact a poison control center or emergency room immediately.
NOTE: This medicine is for your use only. Do not share this medication with others.
How effective is semaglutide for weight loss in non-diabetics?
There have been several anti-obesity medications that help suppress appetite and achieve weight loss. But semaglutide performs on a new level.
An early study of 2,000 obese adults compared people using semaglutide plus a diet and exercise program with people who made the same lifestyle changes without semaglutide. After 68 weeks,
half of the participants using semaglutide lost 15% of their body weight, and nearly a third lost 20%. Participants who incorporated only lifestyle changes lost about 2.4% of their weight.
Since then, additional studies have shown similar results. But they’ve also revealed that participants tend to regain the weight lost when they stop taking semaglutide.
“The fundamentals of obesity management will always be changes to diet and exercise,” Dr. Surampudi says. “But having anti-obesity medications is another tool in the toolbox — depending on the
person’s clinical history.”
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