AOD9604 and tirzepatide are two different substances with distinct mechanisms of action, applications, and regulatory statuses. Here are the key differences between AOD9604 and tirzepatide:
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Chemical Structure:
- AOD9604 is a synthetic peptide derived from a small fragment (177-191) of the human growth hormone (HGH). It is designed to mimic the lipolytic effects of HGH and promote fat metabolism.
- Tirzepatide, on the other hand, is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. It is a larger molecule with a different structure compared to AOD9604.
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Mechanism of Action:
- AOD9604 primarily targets fat metabolism by stimulating lipolysis and promoting the breakdown of stored fat. It aims to induce weight loss without affecting blood sugar levels significantly.
- Tirzepatide works by activating both the GIP and GLP-1 receptors. It has dual actions on glucose metabolism, enhancing insulin secretion and suppressing glucagon release. This results in improved blood sugar control and potential weight loss.
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Applications:
- AOD9604 was initially developed for its potential anti-obesity properties, aiming to reduce body fat while preserving lean muscle mass.
- Tirzepatide is primarily used in the treatment of type 2 diabetes. It helps improve glycemic control and may also lead to weight loss, making it beneficial for individuals with both diabetes and obesity.
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Clinical Status:
- AOD9604 has undergone clinical trials, but its status for medical use is limited, and it has not received widespread approval for specific medical indications.
- Tirzepatide has been studied extensively in clinical trials for its efficacy in treating type 2 diabetes and obesity. As of my knowledge cutoff in January 2022, it has received regulatory approval for certain indications.
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Regulatory Approval:
- AOD9604 has faced controversy and has not received broad regulatory approval for medical use in many countries.
- Tirzepatide has received regulatory approval for the treatment of type 2 diabetes and is being investigated for its potential use in obesity.
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Legal Status:
- The legal status of AOD9604 varies by country, and it may be subject to regulatory restrictions.
- Tirzepatide is a regulated pharmaceutical compound with approved medical uses, and its legal status is governed by health authorities.
It's important to note that the information provided is based on my knowledge as of January 2022, and there may have been developments or changes since then. Individuals should consult with healthcare professionals for the most up-to-date and accurate information on these substances.